Semaglutide Alternatives (2026)
Mimics GLP-1 hormone to reduce appetite and slow stomach emptying. Average weight loss: 15% in clinical trials.
15%
Avg Weight Loss
$149-399/mo
Compounded Price
Weekly
Injection Frequency
5
Dose Options
Alternatives to Semaglutide
If Semaglutide is not the right fit due to cost, availability, side effects, or personal preference, several alternatives exist in the GLP-1 medication class and beyond.
GLP-1 Alternatives
- Tirzepatide: Dual GLP-1/GIP receptor agonist with 20-22% average weight loss ($199-449/mo compounded)
- Liraglutide: GLP-1 receptor agonist with 8% average weight loss ($199-349/mo compounded)
- Wegovy: Brand-name semaglutide for weight loss with 15% average weight loss (N/A compounded)
- Mounjaro: Brand-name tirzepatide for diabetes with 20-22% average weight loss (N/A compounded)
- Ozempic: Brand-name semaglutide for diabetes with 12-15% average weight loss (N/A compounded)
- Retatrutide: GLP-1/GIP/Glucagon triple agonist with 24% average weight loss (Not yet available (pending FDA approval) compounded)
How to Choose
The best alternative depends on your specific needs. Factors to consider include weight loss goals, side effect tolerance, injection frequency preference, insurance coverage, and budget. Your healthcare provider can help you evaluate the options.
Providers Offering Semaglutide
Semaglutide FAQ
How much does Semaglutide cost?
Compounded Semaglutide costs $149-399/mo through telehealth providers. Brand-name versions (Wegovy, Ozempic) cost $1,300+/mo without insurance.
How much weight can I lose on Semaglutide?
Clinical trials show an average weight loss of 15% of body weight on Semaglutide. Individual results vary based on dosage, diet, and exercise habits.
What are Semaglutide side effects?
Common side effects include nausea, diarrhea, constipation, vomiting, headache. Most side effects are temporary and resolve within 4-8 weeks as your body adjusts.
Is Semaglutide taken daily or weekly?
Semaglutide is administered as a weekly subcutaneous injection. It uses a pre-filled pen device for subcutaneous injection.
What doses is Semaglutide available in?
Semaglutide is available in 0.25mg, 0.5mg, 1mg, 1.7mg, 2.4mg doses. Treatment starts at the lowest dose and increases every 4 weeks.