Retatrutide Side Effects (2026)
Simultaneously activates three receptors — GLP-1, GIP, and glucagon — producing stronger appetite suppression and metabolic effects than dual or single agonists. Average weight loss: 24% in clinical trials.
24%
Avg Weight Loss
Not yet available (pending FDA approval)
Compounded Price
Weekly
Injection Frequency
4
Dose Options
Retatrutide Side Effects
Like all GLP-1 medications, Retatrutide can cause side effects. Most are gastrointestinal in nature and resolve within the first 4-8 weeks of treatment.
Common Side Effects
- Nausea
- Diarrhea
- Decreased appetite
- Vomiting
- Constipation
Managing Side Effects
The gradual dose titration schedule is specifically designed to minimize side effects. Additional strategies include eating smaller meals, avoiding fatty foods, staying hydrated, and discussing anti-nausea medication with your provider if needed.
When to Contact Your Provider
Contact your healthcare provider immediately if you experience severe abdominal pain, persistent vomiting, signs of allergic reaction, or any symptom that concerns you. While serious side effects are rare, prompt medical attention is important.
Retatrutide FAQ
How much does Retatrutide cost?
Compounded Retatrutide costs Not yet available (pending FDA approval) through telehealth providers. Brand-name versions (Pending FDA approval) cost Not yet available (Phase 3 trials) without insurance.
How much weight can I lose on Retatrutide?
Clinical trials show an average weight loss of 24% of body weight on Retatrutide. Individual results vary based on dosage, diet, and exercise habits.
What are Retatrutide side effects?
Common side effects include nausea, diarrhea, decreased appetite, vomiting, constipation. Most side effects are temporary and resolve within 4-8 weeks as your body adjusts.
Is Retatrutide taken daily or weekly?
Retatrutide is administered as a weekly subcutaneous injection. It uses a pre-filled pen device for subcutaneous injection.
What doses is Retatrutide available in?
Retatrutide is available in 1mg, 4mg, 8mg, 12mg doses. Treatment starts at the lowest dose and increases every 4 weeks.