Retatrutide Guide (2026)
Simultaneously activates three receptors — GLP-1, GIP, and glucagon — producing stronger appetite suppression and metabolic effects than dual or single agonists. Average weight loss: 24% in clinical trials.
24%
Avg Weight Loss
Not yet available (pending FDA approval)
Compounded Price
Weekly
Injection Frequency
4
Dose Options
What Is Retatrutide?
Retatrutide is a GLP-1/GIP/Glucagon triple agonist that works by simultaneously activates three receptors — glp-1, gip, and glucagon — producing stronger appetite suppression and metabolic effects than dual or single agonists. It was approved by the FDA in Expected 2026-2027 (Phase 3 ongoing) and is manufactured by Eli Lilly. In clinical trials (Phase 3 TRIUMPH trials (ongoing)), patients achieved an average weight loss of 24% of their body weight.
Brand names include Pending FDA approval. Retatrutide is administered as a weekly subcutaneous injection, making it convenient for most patients.
How Retatrutide Works
Simultaneously activates three receptors — GLP-1, GIP, and glucagon — producing stronger appetite suppression and metabolic effects than dual or single agonists. This dual action of reducing hunger and improving metabolic function makes Retatrutide one of the most effective weight loss medications available today.
Who Should Consider Retatrutide?
Retatrutide is prescribed for adults with a BMI of 30 or higher, or a BMI of 27 or higher with at least one weight-related health condition. A licensed healthcare provider will evaluate your eligibility based on your medical history, current medications, and weight loss goals.
Retatrutide FAQ
How much does Retatrutide cost?
Compounded Retatrutide costs Not yet available (pending FDA approval) through telehealth providers. Brand-name versions (Pending FDA approval) cost Not yet available (Phase 3 trials) without insurance.
How much weight can I lose on Retatrutide?
Clinical trials show an average weight loss of 24% of body weight on Retatrutide. Individual results vary based on dosage, diet, and exercise habits.
What are Retatrutide side effects?
Common side effects include nausea, diarrhea, decreased appetite, vomiting, constipation. Most side effects are temporary and resolve within 4-8 weeks as your body adjusts.
Is Retatrutide taken daily or weekly?
Retatrutide is administered as a weekly subcutaneous injection. It uses a pre-filled pen device for subcutaneous injection.
What doses is Retatrutide available in?
Retatrutide is available in 1mg, 4mg, 8mg, 12mg doses. Treatment starts at the lowest dose and increases every 4 weeks.