What Did Retatrutide's Phase 2 Trials Show?
Last updated: January 2026
Quick Answer
Phase 2 NEJM paper (2023): 338 patients, 24 weeks. At 12mg: 17.5% weight loss. Extended to 48 weeks: 24.2% average weight loss. 26% of patients lost ≥30% body weight at 48 weeks. These are the strongest weight loss numbers ever published for a pharmaceutical drug.
What Did Retatrutide's Phase 2 Trials Show
Phase 2 NEJM paper (2023): 338 patients, 24 weeks. At 12mg: 17.5% weight loss. Extended to 48 weeks: 24.2% average weight loss. 26% of patients lost ≥30% body weight at 48 weeks. These are the strongest weight loss numbers ever published for a pharmaceutical drug.
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Related Questions
Retatrutide vs Tirzepatide: Which is More Effective?
Phase 2 data shows retatrutide (24.2% weight loss) outperforms tirzepatide (20.9%). 58% of retatrutide patients lost ≥20% body weight versus 57% for tirzepatide at highest doses. Retatrutide adds a glucagon receptor component that enhances fat burning and metabolic rate.
When Will Retatrutide Be FDA Approved?
Eli Lilly launched the Phase 3 TRIUMPH program in 2024. FDA submission is expected in 2026, with potential approval in 2026-2027. Phase 3 results from the TRIUMPH-3 trial are expected in late 2025.